Thrafford
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Research & patents

Peer-reviewed research, patents and book chapters from our team — spanning CAR-T engineering, drug discovery and pharmacology. Team members are highlighted in author lists.

Research record · 1988–2025

Output by decade · all record types

Showing 92 of 92 entries

2020s6 entries

  1. 2025
    Paper

    Computational modeling and optimization of CAR-T cell receptors targeting CD19 for enhanced efficacy and minimized toxicity

    Kadalmani Krishnan, Anita Chugh, et al.

    Preprint at Research Square

    DOI 10.21203/rs.3.rs-6115435/v2
  2. 2025
    Paper

    Recoding Genomic Elements with AI and Quantum Computation to Build the Next Generation Drug Discovery Platform

    Krishnan, K., Chugh, A., Niranjan, V., & Dhar, P. K.

    Preprints

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  3. 2023
    Paper

    Phase 3 efficacy and safety trial of proposed liraglutide biosimilar for reduction of glycosylated hemoglobin (HbA1c) in patients with Type 2 Diabetes

    Kadalmani Krishnan, Srikar Raman, et al.

    Diabetes Research and Clinical Practice

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  4. 2023
    Paper

    A comprehensive molecular and clinical investigation of approved anti-HCV drugs repurposing against SARS-CoV-2 infection

    Bansode, S.; Singh, P. K.; Tellis, M.; Chugh, A.; et al.

    Vaccines, 11(3), 515

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  5. 2022
    Paper

    Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK

    Natasha S Clayton, et al.

    J Biol Chem

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  6. 2021
    Paper

    Discovery of potential multi-target-directed ligands by targeting host-specific SARS-CoV-2 structurally conserved main protease

    Joshi, R. S.; Jagdale, S. S.; Bansode, S. B.; Shankar, S. S.; Tellis, M. B.; Pandya, V. K.; Chugh, A.; Giri, A. P.; Kulkarni, M. J.

    Journal of Biomolecular Structure and Dynamics, 39(9), 3099-3114. (2021)

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2010s13 entries

  1. 2019
    Paper

    Assembly of novel, nuclear dimers of the PI3-Kinase regulatory subunits underpins the pro-proliferative activity of the Cdc42-activated tyrosine kinase, ACK

    Natasha S. Clayton, Millie Fox, Jose J. Vicenté-Garcia, Courtney M. Schroeder, Trevor D. Littlewood, Jonathan I. Wilde, Jessica Corry, Kadalmani Krishnan, Qifeng Zhang, Michael J. O. Wakelam, Murray J. B. Brown, Claire Crafter, Helen R. Mott, Darerca Owen

    Biorxiv, 2019

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  2. 2017
    Paper

    A2B adenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives

    Basu, Swapan; Barawkar, Debashis A.; Ramdas, Vaibhav; Waman, Yash; Patel, Mehul; Panmand, Amol; Kumar, Sanjeev; Thorat, Sunil; Bonagiri, Rajashekar; Jadhav, Dhananjay; Mukhopadhyay, Pradip; Prasad, Vinay; Reddy, B. S.; Goswami, Anil; Chaturvedi, S.; Menon, S.; Quraishi, A.; Ghosh, Indranil; Dusange, S.; Paliwal, S.; Kulkarni, A.; Karande, Vijay; Thakre, R.; Bedse, G.; Rouduri, S.; Gundu, J.; Palle, V. P.; Chugh, A.; Mookhtiar, K. A.

    European Journal of Medicinal Chemistry, 151, 986-996. (2017)

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  3. 2017
    Paper

    Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A1 receptor antagonists and their biological evaluation

    Koul, S.; Ramdas, V.; Barawkar, Debashis A.; Waman, Yash B.; Prasad, N.; Madadi, S. K.; Shejul, Y. D.; Bonagiri, R.; Basu, Swapan; Menon, S.; Reddy, S. B.; Chaturvedi, S.; Chennamaneni, S. R.; Bedse, G.; Thakare, R.; Gundu, J.; Chaudhary, S.; De, S.; Meru, A. V.; Palle, V.; Chugh, A.; Mookhtiar, K. A.

    Bioorganic & Medicinal Chemistry, 25(6), 1963-1975. (2017)

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  4. 2017
    Paper

    Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia

    Deshpande, Anil M.; Bhuniya, Debnath; De, Siddhartha; Dave, B.; Vyavahare, V. P.; Kurhade, S. H.; Kandalkar, S. R.; Naik, K. P.; Kobal, B. S.; Kaduskar, R. D.; Basu, Swapan; Jain, V.; Patil, P.; Chaturvedi, S.; Joshi, S.; Bhat, G.; Raje, A. A.; Reddy, S.; Gundu, J.; Madgula, V.; Tambe, S.; Shitole, P.; Umrani, D.; Chugh, A.; Palle, V. P.; Mookhtiar, K. A.

    European Journal of Medicinal Chemistry, 133, 268-286. (2017)

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  5. 2016
    Paper

    Discovery of a liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemic potential

    Deshpande, Anil; Bhuniya, Debnath; De, Siddhartha; Umrani, Dhananjay; Madgula, Vamsi; Chugh, Anita; Palle, Venkata; Mookhtiar, Kasim

    251st ACS National Meeting & Exposition, San Diego, CA, United States, March 13-17, 2016 (2016), MEDI-379

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  6. 2015
    Granted patent

    2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application

    Mookhtiar, Kasim A.; Bhuniya, Debnath; Dave, Bhavesh; Kapkoti, Gobind S.; Basu, Sujay; Chugh, Anita; et al.

    Patent Number: 8940900. Filed: Feb 25, 2008. Date: Jan 27, 2015. Assignee: Advinus Therapeutics Private Limited

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  7. 2012
    Paper

    Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase

    Barawkar, Dinesh A.; Bandyopadhyay, Anish; Deshpande, Anil; Koul, Summon; Kandalkar, Sachin; Patil, Pradeep; Khose, Goraksha; Vyas, Samir; Mone, Mahesh; Bhosale, Shubhangi; et al.

    Bioorganic & Medicinal Chemistry Letters (2012), 22(13), 4341-4347

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  8. 2011
    Paper

    Potent and Selective Inhibitors of Long Chain L-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats

    Barawkar, Dinesh A.; Meru, Ashwin; Bandyopadhyay, Anish; Banerjee, Abir; Deshpande, Anil M.; Athare, Chandrashekhar; Koduru, Chandrasekhar; Khose, Goraksha; Gundu, Jayasagar; Mahajan, Koshu; et al.

    ACS Medicinal Chemistry Letters (2011), 2(12), 919-923

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  9. 2011
    Paper

    Discovery of a potent and selective small molecule hGPR91 antagonist

    Bhuniya, Debnath; Umrani, Dhananjay; Dave, Bhavesh; Salunke, Deepak; Kukreja, Gagan; Gundu, Jayasagar; Naykodi, Minakshi; Shaikh, Nadim S.; Shitole, Prasad; Kurhade, Santosh; et al.

    Bioorganic & Medicinal Chemistry Letters (2011), 21(12), 3596-3602

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  10. 2011
    Paper

    RBx-0597, a potent, selective and slow-binding inhibitor of dipeptidyl peptidase-IV for the treatment of type 2 diabetes

    Singh, Shuchita; Roy, Subhasis; Sethi, Sachin; Benjamin, Biju; Sundaram, Sindhuja; Khanna, Vivek; Kandalkar, Sachin R.; Pal, Chanchal; Kant, Rajiv; Patra, Ashok Kumar; et al.

    European Journal of Pharmacology (2011), 655(1-3), 121

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  11. 2011
    Granted patent

    Substituted pyrrole derivatives and their use as HMG-CO inhibitors

    Salman, Mohammad; Sattigeri, Jitendra; Kumar, Yatendra; Aryan, Ram Chander; Ramanathan, Vikram Krishna; Chugh, Anita

    Patent Number: 7923467. Filed: May 28, 2004. Date: April 12, 2011. Assignee: Ranbaxy Laboratories

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  12. 2010
    Paper

    AE9C90CB: a novel, bladder-selective muscarinic receptor antagonist for the treatment of overactive bladder

    Sinha, S.; Gupta, S.; Malhotra, S.; Krishna, N. S.; Meru, A. V.; Babu, V.; Bansal, V.; Garg, M.; Kumar, N.; Chugh, A.; et al.

    British Journal of Pharmacology (2010), 160(5), 1119-1127

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  13. 2010
    Filed patent

    Preparation of heterocyclic compounds as adrenergic receptor antagonists

    Sarma, P. K. S.; Kondaskar, A.; Shelke, S. Y.; Gupta, P.; Pal, A.; Ashani, K.; Sharma, S.; Chugh, A.; Tiwari, A.; Dharmarajan, S.

    IN 2005DE03142 A 20100305

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2000s61 entries

  1. 2009
    Paper

    Ratiometric Ca+2 measurement in human recombinant muscarinic receptor subtypes using the Flexstation scanning fluorometer

    Gupta, Suman; Singh, Rakesh Kumar; Nanda, Kamna; Chatterjee, Mou; Tiwari, Atul; Sundaram, Sindhuja; Gupta, Dikshi; Chugh, Anita; Dastidar, Sunanda; Ray, Abhijit

    Journal of Receptors and Signal Transduction (2009), 29(2), 100-106

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  2. 2009
    Paper

    RBx 6198: A novel α1-adrenoceptor antagonist for the treatment of benign prostatic hyperplasia

    Nanda, Kamna; Naruganahalli, Krishna S.; Gupta, Suman; Malhotra, Shivani; Tiwari, Atul; Hegde, Laxminarayan G.; Jain, Sanjay; Sinha, Neelima; Gupta, Jung B.; Chugh, Anita; et al.

    European Journal of Pharmacology (2009), 607(1-3), 213-219

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  3. 2009
    Filed patent

    Preparation of 3,6-disubstituted azabicyclo[3.1.0]hexane derivatives useful as therapeutic muscarinic receptor antagonists

    Salman, M.; Kumar, N.; Kaur, K.; Aeron, S.; Sarma, P. K. S.; Dharmarajan, S.; Mehta, A.; Chugh, A.

    IN 2005DN01810 A 20091009

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  4. 2009
    Filed patent

    A process for the synthesis of 1,4-disubstituted piperazine derivatives

    Anand, N.; Jain, S.; Sinha, N.; Chugh, A.; Hegde, L. G.; Gupta, J. B.

    IN 2005DE02911 A 20090731

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  5. 2008
    Paper

    Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors

    Sattigeri, Jitendra A.; Andappan, Murugaiah M. S.; Kishore, Kaushal; Thangathirupathy, Srinivasan; Sundaram, Sinduja; Singh, Shuchita; Sharma, Suchitra; Davis, Joseph A.; Chugh, Anita; Bansal, Vinay S.

    Bioorganic & Medicinal Chemistry Letters (2008), 18(14), 4087-4091

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  6. 2008
    Paper

    Independent origin of 185delAG BRCA1 mutation in an Indian family

    Kadalmani K, Deepa S, Bagavathi S, Anishetty S, Thangaraj K, Gajalakshmi AP

    Neoplasma, 2008, 54(1):51-6

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  7. 2008
    Granted patent

    Azabicyclo derivatives as muscarinic receptor antagonists

    Salman, Mohammad; Mehta, Anita; Sarma, Pakala K. S.; Kumar, Naresh; Dharmarajan, Sankaranarayanan; Kaur, Kirandeep; Chugh, Anita

    Patent Number: 7446123. Filed: Jan 7, 2004. Date: Nov 4, 2008. Assignee: Ranbaxy Laboratories

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  8. 2008
    Filed patent

    Preparation of phenoxythiazolylalkylacetamide derivatives and analogs as glucokinase activators

    Mookhtiar, Kasim A.; Bhuniya, Debnath; Dave, Bhavesh; Kapkoti, Gobind S.; Basu, Sujay; Chugh, Anita; De, Siddartha; Palle, Venkata P.

    WO 2008104994 A2 20080904

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  9. 2007
    Paper

    Comparative in vivo uroselectivity profiles of anticholinergics, tested in a novel anesthetized rabbit model

    Naruganahalli, Krishna S.; Sinha, Sandeep; Hegde, Laxminarayan G.; Meru, Ashwinkumar V.; Chugh, Anita; Kumar, Naresh; Gupta, Jung B.; Ray, Abhijit

    European Journal of Pharmacology (2007), 572(2-3), 207-212

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  10. 2007
    Paper

    Synthesis and optimization of novel and selective muscarinic M3 receptor antagonists

    Kumar, Naresh; Kaur, Kirandeep; Aeron, Shelly; Dharmarajan, Sankaranarayanan; Silamkoti, Arun D. V.; Mehta, Anita; Gupta, Suman; Chugh, Anita; Gupta, Jang B.; Salman, Mohammad; et al.

    Bioorganic & Medicinal Chemistry Letters (2007), 17(18), 5256-5260

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  11. 2007
    Paper

    Role of peripheral 5-HT1A receptors in detrusor over activity associated with partial bladder outlet obstruction in female rats

    Mittra, Shivani; Malhotra, Shivani; Naruganahalli, Krishna S.; Chugh, Anita

    European Journal of Pharmacology (2007), 561(1-3), 189-193

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  12. 2007
    Filed patent

    Preparation of azabicyclo[2.2.1]heptyl compounds as muscarinic receptor antagonists for treating respiratory, urinary, and gastrointestinal disorders

    Kumar, Naresh; Cliffe, Ian Anthony; Salman, Mohammad; Palle, Venkata P.; Kaur, Kirandeep; Shejul, Yogesh D.; Chugh, Anita; Gupta, Suman; Ray, Abhijit; Malhotra, Shivani; et al.

    WO 2007110782 A1 20071004

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  13. 2007
    Filed patent

    Quinazoline derivatives as adrenergic receptor antagonists and their preparation, pharmaceutical compositions and use in the treatment of diseases

    Sarma, Pakala Kumara Savithru; Dharmarajan, Sankaranarayanan; Pal, Arani; Kondaskar, Atul; Ashani, K.; Shelka, Sandeep Y.; Gupta, Praful; Sharma, Somesh; Chugh, Anita; Tiwari, Atul; et al.

    IN 2005DE01706 A 20070831

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  14. 2007
    Filed patent

    Thiazolidinedione derivatives as adrenergic receptor antagonists and their preparation, pharmaceutical compositions and use in the treatment of diseases

    Sarma, Pakala Kumara Savithru; Ashani, K.; Gupta, Praful; Pal, Arani; Sharma, Somesh; Chugh, Anita; Tiwari, Atul; Nanda, Kamna

    IN 2005DE01704 A 20070831

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  15. 2007
    Filed patent

    Piperazine derivatives as adrenergic receptor antagonists and their preparation, pharmaceutical compositions and use in the treatment of diseases

    Sarma, Pakala Kumara Savithru; Sharma, Somesh; Dharmarajan, Sankaranarayanan; Ashani, K.; Chugh, Anita; Tiwari, Atul

    IN 2006DE00146 A 20070824

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  16. 2007
    Filed patent

    Preparation of imidazole derivatives as muscarinic receptor antagonists

    Kumar, Naresh; Kaur, Jaskiran; Palle, Venkata P.; Bhatt, Beenu; Jindal, Shelly; Chugh, Anita; Gupta, Suman; Ray, Abhijit; Malhotra, Shivani; Shirumalla, Raj Kumar

    WO 2007077510 A2 20070712

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  17. 2007
    Filed patent

    Preparation of 3-azabicyclo[3.2.1] octanes as muscarinic M3 receptor antagonists

    Kumar, Naresh; Kaur, Kirandeep; Gupta, Suman; Chugh, Anita; Salman, Mohammad; Shirumalla, Raj Kumar; Malhotra, Shivani

    WO 2007039884 A1 20070412

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  18. 2007
    Filed patent

    Derivatives of 3-azabicyclo[3.1.0]hexane as dipeptidyl peptidase-IV inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases

    Sattigeri, Jitendra A.; Andappan, Murugaiah M S.; Kishore, Kaushal; Sethi, Sachin; Kandalkar, Sachin Ramesh; Pal, Chanchal Kumar; Mahajan, Dipak C.; Ahmed, Shahadat; Parkale, Santhosh Sadashiv; Srinivasan, T.; et al.

    WO 2007029086 A2 20070315

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  19. 2007
    Filed patent

    Isoindoledione derivatives, processes for preparing them, pharmaceutical compositions containing them, and their uses as adrenergic receptor antagonists

    Sarma, Pakala Kumara Savithru; Kuttan, Ashani; Pal, Arani; Kondaskar, Atul; Gupta, Praful; Dharmarajan, Sankaranarayanan; Shelke, Sandeep Y.; Sharma, Somesh; Chugh, Anita; Tiwari, Atul

    WO 2007029156 A2 20070315

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  20. 2007
    Filed patent

    Preparation of succinimide and glutarimide piperidine and piperazine derivatives as α1a and/or α1d adrenergic receptor antagonists for treatment of benign prostatic hypertrophy

    Sarma, Pakala Kumara Savithru; Shelke, Sandeep Y.; Ashani, K.; Gupta, Praful; Pal, Arani; Kondaskar, Atul; Dharmarajan, Sankaranarayanan; Sharma, Somesh; Chugh, Anita; Tiwari, Atul

    WO 2007029078 A2 20070315

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  21. 2007
    Filed patent

    Preparation of azabicyclic compounds as muscarinic receptor antagonists

    Kumar, Naresh; Kaur, Kirandeep; Sinha, Sandeep; Gupta, Suman; Palle, Venkata P.; Chugh, Anita

    WO 2007007282 A2 20070118

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  22. 2007
    Filed patent

    Preparation of isoquinoline derivatives as muscarinic receptor antagonists

    Kumar, Naresh; Salman, Mohammad; Kaur, Kirandeep; Chugh, Anita; Sinha, Sandeep

    WO 2007007281 A2 20070118

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  23. 2006
    Paper

    Molecular cloning, stable expression and cellular localization of human α1-adrenergic receptor subtypes: effect of charcoal/dextran treated serum on expression and localization of α1D-adrenergic receptor

    Khattar, Sunil K.; Bora, Roop Singh; Priyadarsiny, Priyanka; Gautam, Aarti; Gupta, Dikshi; Tiwari, Atul; Nanda, Kamna; Singh, Rahul; Chugh, Anita; Bansal, Vinay; et al.

    Biotechnology Letters (2006), 28(21), 1731-1739. DOI:10.1007/s10529-006-9148-x

    DOI 10.1007/s10529-006-9148-x
  24. 2006
    Paper

    Statins and myotoxicity: a therapeutic limitation

    Tiwari, Atul; Bansal, Vinay; Chugh, Anita; Mookhtiar, Kasim

    Expert Opinion on Drug Safety (2006), 5(5), 651-666

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  25. 2006
    Paper

    Intermittent claudication: an overview

    Meru, Ashwinkumar V.; Mittra, Shivani; Thyagarajan, Baskaran; Chugh, Anita

    Atherosclerosis (Amsterdam, Netherlands) (2006), 187(2), 221-237

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  26. 2006
    Paper

    High level stable expression of pharmacologically active human M1-M5 muscarinic receptor subtypes in mammalian cells

    Khattar, Sunil K.; Bora, Roop Singh; Priyadarsiny, Priyanka; Gupta, Dikshi; Khanna, Alka; Narayanan, K. Lakshmi; Babu, Venkatesh; Chugh, Anita; Saini, Kulvinder Singh

    Biotechnology Letters (2006), 28(2), 121-129

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  27. 2006
    Filed patent

    Preparation of benzotriazinones and phenoxazines as α1 adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia

    Sarma, Pakala Kumara Savithru; Sharma, Somesh; Dharmarajan, Sankaranarayanan; Shelke, Sandeep Y.; Pal, Arani; Kondaskar, Atul; Gupta, Praful; Chugh, Anita; Tiwari, Atul; Nanda, Kamna

    WO 2006117760 A1 20061109

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  28. 2006
    Filed patent

    Preparation of 3,6-disubstituted azabicyclo[3.1.0]hexane derivatives as muscarinic receptor antagonists for use against respiratory, urinary and gastrointestinal diseases

    Salman, Mohammad; Kumar, Naresh; Kaur, Kirandeep; Aeron, Shelly; Sarma, Pakala Kumara Savithru; Dharmarajan, Sankaranarayanan; Mehta, Anita; Chugh, Anita

    WO 2006117754 A1 20061109

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  29. 2006
    Filed patent

    Metabolites of 2-{3-[4-(2-isopropoxyphenyl) piperazin-1-yl]-propyl}-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione

    Anand, Nitya; Salman, Mohammad; Yadav, Gyan Chand; Sharma, Somesh; Jain, Sanjay; Sinha, Neelima; Kapkoti, Gobind Singh; Chugh, Anita; Varshney, Brijesh; Paliwal, Jyoti Kumar; et al.

    WO 2006092710 A1 20060908

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  30. 2006
    Filed patent

    Azabicyclic compounds as muscarinic receptor antagonists and their preparation, pharmaceutical compositions and use for treatment of disease of the respiratory, urinary and gastrointestinal systems

    Kumar, Naresh; Salman, Mohammad; Kaur, Kirandeep; Mehta, Anita; Arora, Sudershan K.; Chugh, Anita

    WO 2006054162 A1 20060526

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  31. 2006
    Filed patent

    Isoindole derivatives as adrenergic receptor antagonists and their preparation, pharmaceutical compositions, and use for treatment of benign prostatic hyperplasia

    Salman, Mohammad; Anand, Nitya; Yadav, Gyan Chand; Sharma, Somesh; Kapkoti, Gobind Singh; Chugh, Anita; Nanda, Kamna

    WO 2006051374 A2 20060518

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  32. 2006
    Filed patent

    Alkynylpiperazine derivatives as α1-adrenergic receptor antagonists, their preparation, pharmaceutical compositions, and use in therapy

    Salman, Mohammad; Anand, Nitya; Sharma, Somesh; Kapkoti, Gobind Singh; Chugh, Anita; Nanda, Kamna

    WO 2006051399 A1 20060518

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  33. 2006
    Filed patent

    3-Azabicyclo[3.1.0]hexane derivatives as muscarinic receptor antagonists and their preparation, pharmaceutical compositions, and use for treatment of prophylaxis of respiratory, urinary, or gastrointestinal diseases

    Mehta, Anita; Salman, Mohammad; Sarma, Pakala Kumara Savithru; Aeron, Shelley; Chugh, Anita; Gupta, Suman

    WO 2006035282 A2 20060406

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  34. 2006
    Filed patent

    Azabicyclic compounds as muscarinic receptor antagonists and their preparation, pharmaceutical compositions, and use for treatment of prophylaxis of respiratory, urinary, or gastrointestinal diseases

    Salman, Mohammad; Sarma, Pakala Kumara Savithru; Pal, Arani; Chugh, Anita; Gupta, Suman

    WO 2006035303 A1 20060406

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  35. 2006
    Filed patent

    Preparation of 3,4-dihydroisoquinoline derivatives as muscarinic receptor antagonists for the treatment of respiratory, urinary and gastrointestinal diseases

    Salman, Mohammad; Mehta, Anita; Kumar, Naresh; Kaur, Kirandeep; Silamkoti, Arundutt Viswanatham; Miriyala, Bruhaspathy; Aeron, Shelley; Chugh, Anita

    WO 2006035280 A1 20060406

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  36. 2006
    Filed patent

    Preparation of phenyl-substituted amine diols and related compounds as muscarinic receptor antagonists for treating diseases such as those of the respiratory, urinary and gastrointestinal systems

    Salman, Mohammad; Sarma, Pakala Kumara Savithru; Dharmarajan, Sankaranarayanan; Chugh, Anita; Gupta, Suman

    WO 2006032994 A2 20060330

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  37. 2006
    Filed patent

    Preparation of piperazine derivatives as adrenergic receptor antagonists

    Salman, Mohammad; Anand, Nitya; Sharma, Somesh; Kapkoti, Gobind Singh; Chugh, Anita; Nanda, Kamna

    WO 2006018815 A1 20060223

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  38. 2006
    Filed patent

    Preparation of pyrrolidine derivatives as muscarinic receptor antagonists

    Salman, Mohammad; Sarma, Pakala Kumara Savithru; Shelke, Sandeep Y.; Chugh, Anita; Gupta, Suman

    WO 2006018708 A2 20060223

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  39. 2006
    Filed patent

    Preparation of tetrahydronaphthyl azabicyclo[3.1.0] hexanes as muscarinic receptor antagonists

    Salman, Mohammad; Sarma, Pakala Kumara Savithru; Kondaskar, Atul; Chugh, Anita; Gupta, Suman

    WO 2006016245 A1 20060216

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  40. 2006
    Filed patent

    Preparation of thiazolidinediones as adrenergic receptor antagonists

    Anand, Nitya; Salman, Mohammad; Sharma, Somesh; Kapkoti, Gobind Singh; Chugh, Anita; Nanda, Kamna; Sarma, Pakala Kumara Savithru

    WO 2006013445 A2 20060209

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  41. 2006
    Filed patent

    Preparation of 9H-xanthene-9-carboxylic esters and related compounds as muscarinic receptor antagonists

    Mehta, Anita; Salman, Mohammad; Sarma, Pakala, Kumara, Savithru; Chugh, Anita; Gupta, Suman

    WO 2006005980 A1 20060119

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  42. 2005
    Paper

    Benign prostatic hyperplasia: an insight into current investigational medical therapies

    Tiwari, Atul; Krishna, N. S.; Nanda, Kamna; Chugh, Anita

    Expert Opinion on Investigational Drugs (2005), 14(11), 1359-1372

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  43. 2005
    Paper

    Design, synthesis and activity of novel derivatives of Oxybutynin and Tolterodine

    Kaur, Kirandeep; Aeron, Shelly; Bruhaspathy, Miriyala; Shetty, Shankar J.; Gupta, Suman; Hegde, Laxminarayan H.; Silamkoti, Arun D. V.; Mehta, Anita; Chugh, Anita; Gupta, Jang B.; et al.

    Bioorganic & Medicinal Chemistry Letters (2005), 15(8), 2093-2096

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  44. 2005
    Filed patent

    1,4-Disubstituted piperazine derivatives useful as uro-selective α1-adrenoreceptor blockers

    Anand, Nitya; Jain, Sanjay; Sinha, Neelima; Chugh, Anita; Hegde, Laxminarayan G.; Gupta, Jang Bahadur

    IN 2002DE00449 A 20050311

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  45. 2005
    Filed patent

    Preparation of piperazine derivatives, particularly piperazinyl-pyrrolidine-2,5-dione, piperazinyl-tetrahydroisoindole-1,3-dione, and piperazinyl-piperidine-2,6-dione derivatives, as adrenergic receptor antagonists for treating benign prostatic hyperplasia

    Salman, Mohammad; Sharma, Somesh; Yadav, Gyan Chand; Kapkoti, Gobind Singh; Mishra, Anurag; Gupta, Praful; Anand, Nitya; Chugh, Anita; Nanda, Kamna

    WO 2005118537 A2 20051215

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  46. 2005
    Filed patent

    Preparation of condensed piperidine compounds acting as adrenergic receptor antagonists useful in the treatment of prostatic hyperplasia and lower urinary symptoms

    Anand, Nitya; Salman, Mohammad; Yadav, Gyan Chand; Sharma, Somesh; Kapkoti, Gobind Singh; Chugh, Anita; Nanda, Kamna

    WO 2005118591 A1 20051215

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  47. 2005
    Filed patent

    Preparation of piperazinyl cyclohexyl heterocycles as adrenergic receptor antagonists

    Salman, Mohammad; Sharma, Somesh; Kapkoti, Gobind Singh; Anand, Nitya; Chugh, Anita

    WO 2005113498 A1 20051201

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  48. 2005
    Filed patent

    Combination therapy using adrenergic receptor antagonist in combination with muscarinic receptor antagonists and testosterone 5-reductase inhibitors for lower urinary tract symptoms

    Chugh, Anita; Tiwari, Atul

    WO 2005092341 A1 20051006

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  49. 2005
    Filed patent

    Preparation of 1-alkylpiperazinyl-pyrrolidin-2,5-dione derivatives as adrenergic receptor antagonists for treating benign prostatic hyperplasia

    Anand, Nitya; Salman, Mohammad; Sharma, Somesh; Kapkoti, Gobind Singh; Gupta, Praful; Mishra, Anurag; Chugh, Anita; Tiwari, Atul

    WO 2005037282 A1 20050428

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  50. 2005
    Filed patent

    1-(Alkylpiperazinyl) pyrrolidine-2,5-dione derivatives, particularly 3,4-substituted -[3-[4-(2-alkoxyphenyl) piperazin-1-yl]propyl]pyrrolidine-2,5-diones, as adrenergic receptor antagonists, and their preparation, pharmaceutical compositions, and use in the treatment of benign prostatic hyperplasia and urinary symptoms

    Anand, Nitya; Salman, Mohammad; Sharma, Somesh; Yadav, Gyan Chand; Chugh, Anita

    WO 2005037281 A1 20050428

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  51. 2005
    Filed patent

    Preparation of metabolites and prodrugs of 1-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl] piperidine-2,6-dione for use in the treatment of benign prostatic hyperplasia

    Yadav, Gyan Chand; Sharma, Somesh; Kapkoti, Gobind Singh; Mehta, Anita; Jain, Sanjay; Sinha, Neelima; Chugh, Anita; Paliwal, Jyoti Kumar; Anand, Nitya

    WO 2005018643 A1 20050303

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  52. 2004
    Paper

    A study on hereditary breast cancer patients – Bioinformatic and Experimental approaches

    Kadalmani K, Anishetty S, Gajalakshmi AP

    Indo-Australian Conf. on Medical Biotechnology, proc. p.84

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  53. 2004
    Filed patent

    Preparation of substituted pyrrole derivatives as 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors

    Salman, Mohammad; Sattigeri, Jitendra; Kumar, Yatendra; Aryan, Ram Chander; Ramanathan, Vikram Krishna; Chugh, Anita

    WO 2004106299 A2 20041209

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  54. 2003
    Paper

    Squalene epoxidase as hypocholesterolemic drug target revisited

    Chugh, Anita; Ray, Abhijit; Gupta, Jung B.

    Progress in Lipid Research (2003), 42(1), 37-50

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  55. 2003
    Filed patent

    Preparation of α,ω-dicarboximides as α1-adrenoceptor receptor antagonists for treatment of benign prostatic hyperplasia

    Salman, Mohammad; Yadav, Gyan Chand; Sharma, Somesh; Kapkoti, Gobind Singh; Chugh, Anita; Gupta, Jang Bahadur; Anand, Nitya

    WO 2003084928 A1 20031016

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  56. 2003
    Filed patent

    Preparation of N-(piperazinylpropyl)carboxamides as α1-adrenoceptor receptor antagonists for treatment of benign prostatic hyperplasia

    Salman, Mohammad; Yadav, Gyan Chand; Sharma, Somesh; Kapkoti, Gobind Singh; Chugh, Anita; Gupta, Jang Bahadur; Anand, Nitya

    WO 2003084541 A1 20031016

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  57. 2003
    Book chapter

    Digitalis and newer positive inotropic agents

    Gupta, Y.K., & Chugh, A.

    In S.D. Seth, S.K. Manchanda, & S. Seth (Eds.), Recent advances in cardiovascular therapy of cardiovascular diseases. Jaypee Brothers Medical Publishers

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  58. 2002
    Filed patent

    Preparation of 2-[(4-arylpiperazino) alkyl]isindolediones as α1-adrenoceptor antagonists

    Anand, Nitya; Jain, Sanjay; Sinha, Neelima; Chugh, Anita; Hegde, Laxminarayan G.; Gupta, Jang Bahadur

    WO 2002044151 A1 20020606

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  59. 2001
    Paper

    Differential regulation of striatal G protein levels following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration in C57 BL/6 mice

    Marcotte, E. R.; Chugh, A.; Barlas, C.; Mishra, R. K.

    Neuroscience Letters (2001), 306(1-2), 21-24

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  60. 2001
    Book chapter

    Endothelin receptors: Targets for drug development

    Ray, A.; Hegde, L. G.; Chugh, A.; Gupta, J. B.

    In: Gupta, S.K. Pharmacology and Therapeutics in the New Millennium, New Delhi, India, Dec 1999 (2001), 18-24

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  61. 2000
    Paper

    Endothelin-receptor antagonists: current and future perspectives

    Ray, A.; Hegde, L. G.; Chugh, A.; Gupta, J. B.

    Drug Discovery Today (2000), 5(10), 455-464

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1990s5 entries

  1. 1998
    Paper

    Protection against MPTP treatment by an analog of Pro-Leu-Gly-NH2 (PLG, MIF-1)

    Marcotte, Eric R.; Chugh, Anita; Mishra, Ram K.; Johnson, Rodney L.

    Peptides (New York) (1998), 19(2), 403-406

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  2. 1998
    Paper

    Development of neurogenic pulmonary edema at different grades of intracranial pressure in cats

    Gupta Y K; Chugh A; Kacker V; Mehta V S; Tandon P N

    Indian journal of physiology and pharmacology (1998), 42(1), 71-80

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  3. 1997
    Paper

    Modulation of dopamine receptor agonist-induced rotational behavior in 6-OHDA-lesioned rats by a peptidomimetic analog of Pro-Leu-Gly-NH2 (PLG)

    Mishra, Ram K.; Marcotte, Eric R.; Chugh, Anita; Barlas, Cia; Whan, Deborah; Johnson, Rodney L.

    Peptides (New York) (1997), 18(8), 1209-1215

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  4. 1995
    Paper

    Modulation of N-methyl-D-aspartate (NMDA) antagonist-induced darting behavior by the peptidomimetic PAMTA

    Savelli, J. E.; Chugh, A.; Cheng, C.; Mishra, R. K.; Johnson, R. L.

    Brain Research (1995), 682(1,2), 41-9

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  5. 1991
    Paper

    Modulation of morphine-induced antinociception by intracerebroventricularly administered captopril

    Gupta, Y. K.; Chugh, A.; Arora, S.; Seth, S. D.

    Indian Journal of Experimental Biology (1991), 29(6), 543-5

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1980s6 entries

  1. 1989
    Paper

    Cisplatin-induced emesis: effect of chemoreceptor trigger zone ablation in dogs

    Bhandari, P.; Gupta, Y. K.; Seth, S. D.; Chugh, A.

    Asia Pacific Journal of Pharmacology (1989), 4(3), 209-11

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  2. 1989
    Paper

    Effect of intracerebroventricular administration of angiotensin II on emetic reflex in dogs

    Gupta, Y. K.; Chugh, A.; Bhandari, P.; Seth, S. D.

    Indian Journal of Experimental Biology (1989), 27(6), 576-7

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  3. 1989
    Paper

    Role of endogenous opioids and histamine in morphine induced emesis

    Gupta, Y. K.; Bhandari, P.; Chugh, A.; Seth, S. D.; Dixit, K. S.; Bhargava, K. P.

    Indian Journal of Experimental Biology (1989), 27(1), 52-4

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  4. 1989
    Paper

    Opposing effect of apomorphine on antinociceptive activity of morphine: a dose-dependent phenomenon

    Gupta, Y. K.; Chugh, Anita; Seth, S. D.

    Pain (1989), 36(2), 263-9

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  5. 1988
    Paper

    Characterization of dopamine receptor subtypes in chemoreceptor trigger zone involved in emesis in dogs

    Chugh, A.; Gupta, Y. K.; Bhandari, P.; Seth, S. D.

    Asia Pacific Journal of Pharmacology (1988), 3(3), 135-9

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  6. 1988
    Paper

    Emetic profile of cisplatin in dogs

    Bhandari, P.; Gupta, Y. K.; Seth, S. D.; Chugh, A.

    Asia Pacific Journal of Pharmacology (1988), 3(3), 131-3

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Undated1 entry

  1. —
    Filed patent

    Preparation of (R)-(-)-5-[2-[[2-(2-ethoxyphenoxy)-ethyl]amino]propyl]-2-hydroxybenzenesulfonamide as an α1 adrenergic antagonist

    Kumar, Yatendra; Aryan, Ram Chander; Gowrish

    Citation incomplete in our records — full details to be added.

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